Arid3a ELISA Kit for Mouse(Mus musculus) | EIAab.comArid3a ELISA Kit for Mouse(Mus musculus)

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Arid3a (Gene name),

AT-rich interactive domain-containing protein 3A (Protein name ), ARI3A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Arid3a(Dri1;Dril1);

Protein name:

AT-rich interactive domain-containing protein 3A(ARID domain-containing protein 3A);

Alternative:

Dead ringer-like protein 1;B-cell regulator of IgH transcription(Bright);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Heterodimer with ARID3B. Interacts with E2F1 (By similarity). Interacts with GTF2I and BTK.

Function:

Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway.

Subcellular Location:

Nucleus Cytoplasm Shuttles between nucleus and cytoplasm.

Protein Attributes:

Sequence length:

601

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

601:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q62431

UniGene:

Mm.301282

Pfam:

PF01388

STRING:

10090.ENSMUSP00000019708

String:

Q62431

KEGG:

mmu:13496

Uniprot:

Q62431

FOR

ELISA Kit for Mouse ARID domain-containing protein 3A

Cat.:

E14648m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse ARID domain-containing protein 3A

Cat.:

E14648h

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Manual:

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Packing:

96T

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CLIA Kit for Mouse ARID domain-containing protein 3A

Cat.:

U14648m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse ARID domain-containing protein 3A

Cat.:

U14648h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse ARID domain-containing protein 3A

Cat.:

P14648Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse ARID domain-containing protein 3A

Cat.:

P14648Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse ARID domain-containing protein 3A

Protein for Mouse ARID domain-containing protein 3A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family."
Herrscher R.F. , Kaplan M.H. , Lelsz D.L. , Das C. , Scheuermann R. , Tucker P.W.
Genes Dev.9:3067-3082(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6.
tissue: Brain.
4.

"Expression of bright at two distinct stages of B lymphocyte development."
Webb C.F. , Smith E.A. , Medina K.L. , Buchanan K.L. , Smithson G. , Dou S.
J. Immunol.160:4747-4754(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
5.

"The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease."
Webb C.F. , Yamashita Y. , Ayers N. , Evetts S. , Paulin Y. , Conley M.E. , Smith E.A.
J. Immunol.165:6956-6965(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BTK
6.

"Transcriptional activation by a matrix associating region-binding protein. contextual requirements for the function of bright."
Kaplan M.H. , Zong R.-T. , Herrscher R.F. , Scheuermann R.H. , Tucker P.W.
J. Biol. Chem.276:21325-21330(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Mutations in the DNA-binding domain of the transcription factor Bright act as dominant negative proteins and interfere with immunoglobulin transactivation."
Nixon J.C. , Rajaiya J. , Webb C.F.
J. Biol. Chem.279:52465-52472(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF PRO-268; TRP-299; PHE-317 AND TYR-330
8.

"A regulated nucleocytoplasmic shuttle contributes to Bright's function as a transcriptional activator of immunoglobulin genes."
Kim D. , Tucker P.W.
Mol. Cell. Biol.26:2187-2201(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-457; PRO-463; LYS-466; LYS-467; GLY-532; TYR-535; GLY-537 AND LEU-539
9.

"Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I."
Rajaiya J. , Nixon J.C. , Ayers N. , Desgranges Z.P. , Roy A.L. , Webb C.F.
Mol. Cell. Biol.26:4758-4768(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GTF2I AND BTK
10.

"Anti-nuclear antibody production and autoimmunity in transgenic mice that overexpress the transcription factor Bright."
Shankar M. , Nixon J.C. , Maier S. , Workman J. , Farris A.D. , Webb C.F.
J. Immunol.178:2996-3006(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-127;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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